Qexp-MDx Metabolism Related Genotyping Kit
Obesity has emerged as one of the most serious public health concerns in the twenty-first century. Someone keeps their shape well despite they guzzle down drink or food. Some people go on a diet and exercise but can‘t get rid of the weight they gain. Did you know that obesity is also related to genes in addition to acquired effects!
Currently, common obesity genes include ADRB2, ADRB3, UCP1, PPAR?, GNB3, Sema3, and so on. Qexp-MDx Obesity Genotyping Kit is based on ADRB2, ADRB3, and UCP1 to analyze the risk of obesity.
Beta-2 adrenergic receptor, ADRB2
ADRB2 is a cell membrane-spanning beta-adrenergic receptor. It will couple with catecholamines to activate a series of downstream reactions that promote the decomposition of fat and carbohydrates. ADRB2 has a Guanine (G) mutation from Cytosine (C) at position 79 leading to a decreased efficiency of fat and carbohydrate metabolism and an increased risk of systemic obesity.
Beta-3 adrenergic receptor, ADRB3
The function of ADRB3 is co-related to the ADRB2. The difference is that ADRB3 is involved in intercellular signaling and is responsible for lipolysis and thermogenesis. ADRB3 has a Cytosine (C) mutation from Thymine (T) at position 190. It will lead to easy accumulation of fat and increase the risk of upper-body fat.
Thermogenin, UCP1
UCP1 is a mitochondrial carrier protein found in brown adipose tissue (BAT). UCP1 plays an important role in energy balance by consuming energy from food metabolism to generate heat. UCP1 has a Guanine (G) mutation from Adenine (A) at position 190. It leads to poorer thermogenesis effect and accumulate fat in the thighs and buttocks, resulting in lower-body obesity.
